H. pylori - Ace Infectious
Associations Between Genetic Polymorphisms and Gastrointestinal Diseases
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Associations Between Genetic Polymorphisms and Gastrointestinal Diseases

Both the genetic polymorphisms (GPs) of H. pylori and humans have an impact on the types of gastrointestinal diseases (GDs) caused by H. pylori. Ace Infectious offers genetic polymorphism testing services to help study the associations between GPs and GDs.

GPs and GDs

H. pylori infection can cause a variety of gastrointestinal disorders, including gastritis, gastric ulcers, gastric cancer, and duodenal ulcers. The formation of different diseases caused by H. pylori is associated with GPs in both H. pylori and humans, as well as environmental factors. For example, H. pylori strains with cagA gene have a greater ability to cause disease, and the EPIYA (Glu-Pro-Ile-Tyr-Ala) and multimerization (CM) motifs have been reported to contribute to disease progression. The gene types associated with gastric cancer risk in VacA are the s1, m1, and i1 genotypes. In humans, IL-1β-31T+ and IL-1RN*2/*2 of the IL-1 loci increased the risk of gastric cancer. And individuals carrying the TNF-α-308 have an increased risk of gastric cancer.

Fig. 1 Factors influencing H. pylori’s disease potential in the gastric mucosa (Whitmire & Merrell, 2019)Fig. 1 Factors influencing H. pylori’s disease potential in the gastric mucosa (Whitmire & Merrell, 2019).

Services overview

Ace Infectious provides genetic testing services and data analysis services to help explore the associations between GPs and GDs caused by H. pylori.

The H. pylori genes we offer testing for include vacA, cagA, iceA, hopQ, babA, sabA, and sabB. The human genes we offer testing for include IL-1β, IL-1RN, TNF-a, TLR4, NOD2, and PSCA. Prior to genetic testing, we help to culture H. pylori samples and identify H. pylori through tests such as urease testing. If you have other genetic testing needs, please let us know.

For data analysis services, we offer two types of services. One is the analysis of H. pylori or human GPs based on polymorphism data and disease data from different sources. The second type is the analysis of H. pylori and human polymorphisms on polymorphism data and disease data from different sources. The second type of data analysis contributes to a comprehensive understanding of the relationship between H. pylori GPs, human GPs, and disease progression.

Our strengths

Skilled H. pylori culturists

We have professional H. pylori culture staff who have long experience in culturing H. pylori. They can efficiently culture H. pylori samples to avoid sample loss due to unfavorable culture.

Customized genetic test kits

We have developed genetic test kits for the above genes. We can efficiently perform gene detection and data logging using high-throughput detection methods and real-time data recording.

Professional data analysis

Our bioinformaticians are responsible for analyzing the relationship between GPs and diseases. Usually, logistic regression analysis is used in the analysis. Log-linear modeling is used to assess higher-order associations, fitting a saturated model using categorical variables representing polymorphic genes, disease state, gender, and age.

Collaborate with us

Ace Infectious specializes in H. pylori-related research and provides genetic testing services on clinical H. pylori samples and people sickened by H. pylori to help study the impact of GPs on disease progression. Please contact us for efficient genetic testing services and professional data analysis services.

References

  1. Whitmire, J. M.; Merrell, D. S. Helicobacter pylori genetic polymorphisms in gastric disease development. Helicobacter pylori in Human Diseases. 2019: 173-94.
  2. Clyne, M.; Rowland, M. The role of host genetic polymorphisms in Helicobacter pylori mediated disease outcome. Helicobacter pylori in Human Diseases. 2019: 151-72.

※ All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.